A8842
Sigma
Anti-Amyloid Precursor Protein, KPI Domain antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
| Synonym: | Anti-APP |
| MDL number: | MFCD02095829 |
Description
| Immunogen | synthetic peptide corresponding to the Kunitz Protease Inhibitor (KPI) domain of human APP770 (amino acids 301-315) conjugated to KLH. |
| Specificity | The immunogen sequence is identical in rat and mouse APP770 and in the APP isoform APP751, and is absent in APP695. By immunohistochemistry, the antibody recognizes APP770. |
| Physical form | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
Properties
| antibody form | IgG fraction of antiserum |
| clone | (polyclonal) |
| form | buffered aqueous solution |
| species reactivity | mouse, human, rat |
| application(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using formic acid-treated sections of human Alzheimer's disease (AD) brain |
| microarray: suitable | |
| Gene Information | human ... APP(351) |
| rat ... App(54226) | |
| mouse ... App(11820) | |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| WGK Germany | 3 |
Related Products
| Array | XP725, Panorama® Antibody Microarray - XPRESS Profiler725 Kit |
References
| reference | Aronovich, R., et al., Increased KPI containing amyloid precursor protein in experimental autoimmune encephalomyelitis brains. Neuroreport 18, 581-584, (2007) Abstract |
